#FridayRead

This week’s #Fridayread from the lab of Dr. Natalia Rodriguez-Muela describes the generation of an isogenic panel of hiPSC-derived cortical organoids carrying familial Alzheimer’s disease-associated APP variants or the protective A673T variant. Through the panel of 3D models they identified distinct pathogenic pathways specific to each variant.

This weeks #Fridayread describes a feeder cell-free culture system based on serum coating that supports long-term maintenance of naive human pluripotent stem cells (hPSCs).

This weeks #FridayRead explores disease mechanisms in an autosomal recessive form of Parkinson’s disease caused by mutations in the DJ-1 protein. Parkinson’s disease is neurodegenerative disorder effecting the central and peripheral nervous system, it is common and effects 1% of people over 60.

This weeks #FridayRead explores the role of Nodal and Wnt signaling in mammalian body patterning during gastrulation. They suggest Nodal is responsible for anterior fates and Wnt posterior fates in the development of the mammalian embryonic body plan.

In this weeks #FridayRead we take a detour from stem cells and development into the fascinating field of study into weight and weight loss intervention.

The weeks #Fridayread reports on the development of a patient-derived organoid biobank for the study of chronic pancreatitis and other pancreatic diseases. This will allow the development and testing of targeted therapeutics.