Interleukin-18 (IL-18) is a pro-inflammatory cytokine that activates immune cells, particularly NK and T-cells, enhancing immune responses against infections and playing a role in inflammation regulation.

Where is IL-18 found?

IL-18 is primarily found in immune cells, such as macrophages and dendritic cells, and is also produced in various tissues, including the spleen, liver, and intestines, during inflammation.

Yes, IL-18 is a cytokine, specifically a pro-inflammatory cytokine that plays a crucial role in immune responses by activating T-cells and natural killer (NK) cells.

What does the IL-18 gene do?

The IL-18 gene encodes the interleukin-18 protein.

What does IL-18 bind to?

IL-18 binds to the IL-18 receptor (IL-18R), which consists of two subunits: IL-18Rα and IL-18Rβ.

What is the IL-18 pathway?

When IL-18 binds to its receptor, MyD88 is activated along with and downstream signaling. This leads to MAPK and NF-κB activation, promoting cytokine production, enhancing inflammation, and stimulating T-cell and NK cell responses.

How is IL-18 used in cell culture?

IL-18 is used in cell culture to stimulate immune cells, enhancing T-cell and NK cell activation. It facilitates immune response studies, vaccine development, cancer research, and inflammation models, allowing researchers to investigate immune modulation and disease mechanisms.

Recombinant human IL-21 protein (Qk129)

Product: Qk129 Category: Coming soon

Price range: £320.00 through £3,960.00

Recombinant human IL-21 protein (Qk129) image

Interleukin 21 (IL-21) is a cytokine produced by natural killer (NK) cells and some T cells. IL-21 has broad immunological functions and can regulate NK cells, macrophages, and dendritic cells, as well as playing a role in promoting B cell and antibody responses. Recombinant IL-21 can be used in the differentiation of subsets T cells, NK cells, B cells and plasma cells.

Qkine animal origin-free recombinant human IL-21 will be available soon, contact ryan.weber@matriqx.com for updates and pre-orders.

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Price range: £320.00 through £3,960.00

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